The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
Apr. 24, 2006
Alison A. Mccormick, Vacaville, CA (US);
Mark L. Smith, Davis, CA (US);
Kenneth E. Palmer, Vacaville, CA (US);
John A. Lindbo, Vacaville, CA (US);
Long V. Nguyen, Vacaville, CA (US);
Gregory P. Pogue, Vacaville, CA (US);
Alison A. McCormick, Vacaville, CA (US);
Mark L. Smith, Davis, CA (US);
Kenneth E. Palmer, Vacaville, CA (US);
John A. Lindbo, Vacaville, CA (US);
Long V. Nguyen, Vacaville, CA (US);
Gregory P. Pogue, Vacaville, CA (US);
Kentucky Bioprocessing, LLC, Owensboro, KY (US);
Abstract
Herein-described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.