The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
Nov. 03, 2005
Sean C. Moore, Durham, NC (US);
Sharat Singh, Los Altos, CA (US);
Hossein Salimi-moosavi, Sunnyvale, CA (US);
Liching Cao, Vallejo, CA (US);
Jeff Sperinde, El Granada, CA (US);
Sean C. Moore, Durham, NC (US);
Sharat Singh, Los Altos, CA (US);
Hossein Salimi-Moosavi, Sunnyvale, CA (US);
Liching Cao, Vallejo, CA (US);
Jeff Sperinde, El Granada, CA (US);
Laboratory Corporation of America Holdings, Burlington, NC (US);
Abstract
Methods, compositions and kits are provided for assessing angiogenesis through sensitive, direct detection of activation of endothelial cells at molecular levels. In general, activation of endothelial cells is detected by measuring the levels of cellular components and their protein complexes participating in a specific angiogenesis signaling pathway in endothelial cells. The methods can be used for assessing status of diseases associated with undesirable angiogenesis, such as the likelihood of developing the disease, presence or absence of the disease, prognosis of the disease and the likelihood of response or resistance to a particular anti-angiogenic therapy. The methods can also be used to guide the design of effective therapeutic regimens targeting a specific angiogenic signaling pathway, as well as in conjunction with therapeutic intervention of diseases or conditions associated with undesirable angiogenesis.