The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
Oct. 17, 2007
Antu K. Dey, Auburndale, MA (US);
John P. Moore, New York, NY (US);
William C. Olson, Yorktown Heights, NY (US);
Sai Prasad N. Iyer, East Elmhurst, NY (US);
Yun (Kenneth) Kang, Livingston, NJ (US);
Michael Franti, Cambridge, MA (US);
Antu K. Dey, Auburndale, MA (US);
John P. Moore, New York, NY (US);
William C. Olson, Yorktown Heights, NY (US);
Sai Prasad N. Iyer, East Elmhurst, NY (US);
Yun (Kenneth) Kang, Livingston, NJ (US);
Michael Franti, Cambridge, MA (US);
Progenics Pharmaceuticals Inc., Tarrytown, NY (US);
Abstract
This invention provides a modified gp140 envelope polypeptide of an HIV-1 isolate comprising a gp120 polypeptide portion comprising consecutive amino acids and a gp41 ectodomain polypeptide portion comprising consecutive amino acids, said gp41 ectodomain polypeptide portion being modified to comprise isoleucine (I) at an amino acid position equivalent to amino acid position 535; glutamine (Q) at an amino acid position equivalent to amino acid position 543; serine (S) at an amino acid position equivalent to amino acid position 553; lysine (K) at an amino acid position equivalent to amino acid position 567; and arginine (R) at an amino acid position equivalent to amino acid position 588, the amino acid positions being numbered by reference to the HIV-1 isolate KNH1144. This invention also provides nucleic acids encoding such a polypeptide, vectors, host cells, trimeric complexes and compositions thereof. Also provided are antibodies generated against the modified polypeptides and trimeric complexes, and methods of using the modified polypeptides, compositions and trimeric complexes.