The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
Jan. 11, 2008
Richard Dodel, Weimar a.d. Lahn, DE;
Michael Bacher, Coelbe, DE;
Michael Przybylski, Trebur, DE;
Raluca Stefanescu, Konstanz, DE;
Marilena Manea, Konstanz, DE;
Richard Dodel, Weimar a.d. Lahn, DE;
Michael Bacher, Coelbe, DE;
Michael Przybylski, Trebur, DE;
Raluca Stefanescu, Konstanz, DE;
Marilena Manea, Konstanz, DE;
Philipps-Universitaet Marburg, Marburg, DE;
Abstract
Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided.