The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
May. 11, 2006
Robert Schulingkamp, Warminster, PA (US);
Jianshen Qi, Chalfont, PA (US);
Raymond Colburn, Chalfont, PA (US);
Dennis Stone, Telford, PA (US);
Christopher Van Besien, Cambridge, MA (US);
Lisa Minor, Flemington, NJ (US);
Patricia Andrade-gordon, Doylestown, PA (US);
Bruce Damiano, Warrington, PA (US);
Robert Schulingkamp, Warminster, PA (US);
Jianshen Qi, Chalfont, PA (US);
Raymond Colburn, Chalfont, PA (US);
Dennis Stone, Telford, PA (US);
Christopher Van Besien, Cambridge, MA (US);
Lisa Minor, Flemington, NJ (US);
Patricia Andrade-Gordon, Doylestown, PA (US);
Bruce Damiano, Warrington, PA (US);
Janssen Pharmaceutica NV, , BE;
Abstract
Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the redness or the skin temperature of the ear of an animal, and the use of the methods to test compounds for their abilities to increase or decrease the biological activity of an U-II receptor.