The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2011
Filed:
Jun. 07, 2006
Applicant:
Enrico A. Antonini, Edwardsville, IL (US);
Inventor:
Enrico A. Antonini, Edwardsville, IL (US);
Assignee:
Mallinckrodt Inc., Hazelwood, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 489/02 (2006.01); C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for the purification of an impure preparation containing naltrexone by means of a reverse phase preparative chromatography process is provided. In an illustrative embodiment a chromatographic column is loaded with a stationary phase, typically a silica particle having an organic ligand bound thereto. With a loading ratio of from about 10 to about 1000 the impure preparation is acidified and passed through the column. The column is eluted with typically an aqueous solution with acetonitrile and the purified naltrexone is obtained in a specified fraction.