The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2011
Filed:
Sep. 13, 2004
Ejner Bech Jensen, Virum, DK;
Hans-henrik Kristensen Høgenhaug, Holte, DK;
Peter Kamp Hansen, Lejre, DK;
Poul Erik Pedersen, Soborg, DK;
Per Holse Mygind, Soborg, DK;
Ejner Bech Jensen, Virum, DK;
Hans-Henrik Kristensen Høgenhaug, Holte, DK;
Peter Kamp Hansen, Lejre, DK;
Poul Erik Pedersen, Soborg, DK;
Per Holse Mygind, Soborg, DK;
Novozymes Pharma Biotec A/S, Bagsvaerd, DK;
Abstract
The invention relates to the use of co-expression of an antimicrobial agent and an enzyme, with a view to improving yield and/or overall production economy. Examples of antimicrobial agents are antimicrobial peptides such as lactoferricins and antimicrobial enzymes such as lysozyme and glucose oxidase, and examples of enzymes are endoglucanase, xylanase, phytase, protease, galactanase, mannanase, dextranase, alpha-galactosidase, pectate lyase, alpha-amylase and glucoamylase. A fusion product comprising the antimicrobial agent and the enzyme and a cleavable linker is novel, and can be used in animal feed and animal feed additives. The invention also describes the use of a protection domain wherein at least 50% of the amino acid residues comprised in the peptide protection domain are D (Asp) and/or E (Glu). The protection or quenching domain serves to temporarily and reversibly inactivate the antimicrobial peptide during the expression.