The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 2011
Filed:
Sep. 10, 2008
Mahesh Kumar, Fort Dodge, IA (US);
Muhammad Ayub Khan, Fort Dodge, IA (US);
Mahesh Kumar, Fort Dodge, IA (US);
Muhammad Ayub Khan, Fort Dodge, IA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
The present invention provides live, attenuatedbacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-typebacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuatedbacteria, and methods for making live attenuatedbacteria. An exemplary live, attenuated strain ofis provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine againstinfection in chickens.