The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2011
Filed:
Jul. 19, 2006
Yves Guminski, Lagarrigue, FR;
Martial Grousseaud, Castres, FR;
Thierry Imbert, Viviers les Montagnes, FR;
Yves Guminski, Lagarrigue, FR;
Martial Grousseaud, Castres, FR;
Thierry Imbert, Viviers les Montagnes, FR;
Pierre Fabre Medicament, Boulogne-Billancourt, FR;
Abstract
The invention relates to a method for synthesizing 4.beta.-amino-4'-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4.beta.-halogenoacetamido-4′-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4.beta.-amino-4′-demethyl-4-desoxypodophyllotoxin.