The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2011
Filed:
Jul. 10, 2006
Nicholas Pullen, Sandwich, GB;
Elizabeth Molloy, Sandwich, GB;
Sirid-aimée Kellermann, Menlo Park, CA (US);
Larry L. Green, San Francisco, CA (US);
Mary Haak-frendscho, Newark, CA (US);
Nicholas Pullen, Sandwich, GB;
Elizabeth Molloy, Sandwich, GB;
Sirid-Aimée Kellermann, Menlo Park, CA (US);
Larry L. Green, San Francisco, CA (US);
Mary Haak-Frendscho, Newark, CA (US);
Amgen Fremont Inc., Fremont, CA (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.