The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2011
Filed:
Jun. 22, 2007
Petrus Johannes Louis Spee, Allerød, DK;
Søren Berg Padkær, Værløse, DK;
Birgitte Nissen Friedrichsen, Gentofte, DK;
Inga Sig Nielsen Nørby, Birkerød, DK;
Petrus Johannes Louis Spee, Allerød, DK;
Søren Berg Padkær, Værløse, DK;
Birgitte Nissen Friedrichsen, Gentofte, DK;
Inga Sig Nielsen Nørby, Birkerød, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
Soluble versions of heterodimeric receptors, e.g., CD94/NKG2 receptors, and methods of producing and using such constructs, are described. The constructs comprise soluble fragments of, each receptor monomer, and some constructs further comprise at least one immunoglobulin Fc domain. Exemplary constructs are those wherein (1) each soluble fragment is linked to an immunoglobulin Fc domain, which are then allowed to dimerize, (2) each soluble fragment is linked to an immunoglobulin Fc domain mutated to promote forced dimerization with the correct counterpart, and (3) single-chain constructs where the monomeric receptor fragments are linked, and the C-terminal fragment is linked to an Fc domain.