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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7928133 B1

PDFFull Text
Date of Patent:
Apr. 19, 2011

Filed:

Jul. 24, 2007

Compounds and compositions as hedgehog signaling pathway modulators

Applicants:

Dai Cheng, San Diego, CA (US);

Dong Han, San Diego, CA (US);

Wenqi Gao, San Diego, CA (US);

Jiqing Jiang, San Diego, CA (US);

Shifeng Pan, San Diego, CA (US);

Yongqin Wan, Irvine, CA (US);

Qihui Jin, San Diego, CA (US);

Inventors:

Dai Cheng, San Diego, CA (US);

Dong Han, San Diego, CA (US);

Wenqi Gao, San Diego, CA (US);

Jiqing Jiang, San Diego, CA (US);

Shifeng Pan, San Diego, CA (US);

Yongqin Wan, Irvine, CA (US);

Qihui Jin, San Diego, CA (US);

Assignee:

IRM LLC, Hamilton, BM;

Attorneys:

Scott W. Reid

Genomics Institute of the Novartis Research Foundation

Primary Examiner:

Joseph R Kosack

Assistant Examiner:

Matthew P Coughlin

Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/541 (2006.01); A61K 31/5377 (2006.01); A61K 31/517 (2006.01); A61K 31/4709 (2006.01); A61K 31/454 (2006.01); A61K 31/4439 (2006.01); A61K 31/4375 (2006.01); A61K 31/428 (2006.01); A61K 31/427 (2006.01); A61K 31/423 (2006.01); A61K 31/422 (2006.01); A61K 31/4178 (2006.01); A61K 31/4164 (2006.01); C07D 471/04 (2006.01); C07D 417/14 (2006.01); C07D 413/14 (2006.01); C07D 413/12 (2006.01); C07D 405/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 233/64 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

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