The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 19, 2011

Filed:

Mar. 17, 2008
Applicants:

Aurelia Conte, Basel, CH;

Henrietta Dehmlow, Loerrach, DE;

Uwe Grether, Efringen-Kirchen, DE;

Nicole A. Kratochwil, Sool, CH;

Holger Kuehne, Loerrach, DE;

Robert Narquizian, Saint Louis, FR;

Constantinos G. Panousis, Bottmingen, CH;

Jens-uwe Peters, Grenzach-Wyhlen, DE;

Fabienne Ricklin, Hombourg, FR;

Inventors:

Aurelia Conte, Basel, CH;

Henrietta Dehmlow, Loerrach, DE;

Uwe Grether, Efringen-Kirchen, DE;

Nicole A. Kratochwil, Sool, CH;

Holger Kuehne, Loerrach, DE;

Robert Narquizian, Saint Louis, FR;

Constantinos G. Panousis, Bottmingen, CH;

Jens-Uwe Peters, Grenzach-Wyhlen, DE;

Fabienne Ricklin, Hombourg, FR;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/501 (2006.01); C07D 487/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (I): wherein R, R, R, R, R, X, X, X, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used in treating or preventing diseases which are modulated by HM74A agonists.


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