The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Nov. 21, 2007
Steven M. Menchen, Fremont, CA (US);
Christina E. Inman, San Mateo, CA (US);
Meng Taing, Hayward, CA (US);
Khai Luong, Oakland, CA (US);
Handong LI, San Jose, CA (US);
Steven M. Menchen, Fremont, CA (US);
Christina E. Inman, San Mateo, CA (US);
Meng Taing, Hayward, CA (US);
Khai Luong, Oakland, CA (US);
Handong Li, San Jose, CA (US);
Applied Biosystems, LLC, Carlsbad, CA (US);
Abstract
Intermediates and methods for forming passivated surfaces on oxide layers and articles produced thereby are described. Hydroxyl or hydroxide groups on the oxide surfaces are reacted with a metal reagent of the formula Y(L-Pol), where Y is a transition metal, magnesium or aluminum, L is oxygen, sulfur, selenium or an amine, and 'Pol' represents a passivating agent such as a polyethylene glycol, a hydrocarbon, or a fluorocarbon. The resulting modified surface can be further reacted with a passivating agent having a phosphate functional group or a polyvalent reagent comprising a passivating moiety and a plurality of functional groups that are reactive with or that form complexes with Y. The passivating agent can also include a functional group such as biotin to provide surfaces with a desired functionality. The passivated surfaces exhibit minimal binding to bio-molecules and can be used in single-molecule detection schemes.