The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
May. 23, 2006
Huiyu Cao, Cohoes, NY (US);
Hung-yun Lin, Schenectady, NY (US);
Paul J. Davis, West Sand Lake, NY (US);
Faith B. Davis, West Sand Lake, NY (US);
Huiyu Cao, Cohoes, NY (US);
Hung-Yun Lin, Schenectady, NY (US);
Paul J. Davis, West Sand Lake, NY (US);
Faith B. Davis, West Sand Lake, NY (US);
Ordway Research Institute, Albany, NY (US);
Abstract
Prostaglandin-endoperoxide H synthase (PGHS-2) converts arachidonic acid to prostaglandin H. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-κB regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.