The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Sep. 11, 2003
Örn Almarsson, Shrewsbury, MA (US);
Magali Bourghol Hickey, Medford, MA (US);
Matthew L. Peterson, Framingham, MA (US);
Michael J. Zaworotko, Tampa, FL (US);
Brian Moulton, Providence, RI (US);
Nair Rodriguez-hornedo, Ann Arbor, MI (US);
Örn Almarsson, Shrewsbury, MA (US);
Magali Bourghol Hickey, Medford, MA (US);
Matthew L. Peterson, Framingham, MA (US);
Michael J. Zaworotko, Tampa, FL (US);
Brian Moulton, Providence, RI (US);
Nair Rodriguez-Hornedo, Ann Arbor, MI (US);
University of South Florida, Tampa, FL (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Transform Pharmaceuticals, Inc., Lexington, MA (US);
Abstract
A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, sp2 amine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, s-heterocyclic ring, thiophene, n-heterocyclic ring, pyrrole, o-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.