The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2011
Filed:
Feb. 22, 2005
Edward H. Cohen, Belmont, MA (US);
Isaac J. Rondon, San Francisco, CA (US);
Timothy A. Springer, Newton, MA (US);
Motomu Shimaoka, Brookline, MA (US);
Edward H. Cohen, Belmont, MA (US);
Isaac J. Rondon, San Francisco, CA (US);
Timothy A. Springer, Newton, MA (US);
Motomu Shimaoka, Brookline, MA (US);
The CBR Institute for Biomedical Research, Inc., Boston, MA (US);
Abstract
The disclosure provides, inter alia, binding proteins (e.g., antibodies) that bind to an integrin in an activated conformation, e.g., activated LFA-1 ('aLFA-1'), e.g., relative to a non-activated conformation of LFA-1. In one embodiment, the binding proteins inhibit at least one function of an aLFA-1, e.g., inhibit a binding interaction between aLFA-1 and a cognate ligand of aLFA-1, e.g., an ICAM protein. The binding proteins can be used to treat or prevent an inflammatory disorder or other disorder.