The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2011
Filed:
Sep. 29, 2006
Mark L. Greenlee, Plainfield, NJ (US);
Dongfang Meng, Westfield, NJ (US);
Dann L. Parker, Jr., Cranford, NJ (US);
Wanying Sun, Edison, NJ (US);
Kenneth J. Wildonger, Bridgewater, NJ (US);
Robert R. Wilkening, Maplewood, NJ (US);
Mark L. Greenlee, Plainfield, NJ (US);
Dongfang Meng, Westfield, NJ (US);
Dann L. Parker, Jr., Cranford, NJ (US);
Wanying Sun, Edison, NJ (US);
Kenneth J. Wildonger, Bridgewater, NJ (US);
Robert R. Wilkening, Maplewood, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.