The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2011
Filed:
Aug. 10, 2005
Georges Joseph Cornelius Hoornaert, Kessel-Lo, BE;
Amuri Kilonda, Heverlee, BE;
Jan Heeres, Vosselaar, BE;
Paulus Joannes Lewi, Turnhout, BE;
Marc René DE Jonge, Tilburg, NL;
Frederik Frans Desiré Daeyaert, Beerse, BE;
Hendrik Maarten Vinkers, Antwerp, BE;
Lucien Maria Henricus Koymans, Retie, BE;
Paul Adriaan Jan Janssen, Vosselaar, BE;
Frank Xavier Jozef Herwig Arts, Legal Representative, Brasschaat, BE;
Georges Joseph Cornelius Hoornaert, Kessel-Lo, BE;
Amuri Kilonda, Heverlee, BE;
Jan Heeres, Vosselaar, BE;
Paulus Joannes Lewi, Turnhout, BE;
Marc René de Jonge, Tilburg, NL;
Frederik Frans Desiré Daeyaert, Beerse, BE;
Hendrik Maarten Vinkers, Antwerp, BE;
Lucien Maria Henricus Koymans, Retie, BE;
Paul Adriaan Jan Janssen, Vosselaar, BE;
Frank Xavier Jozef Herwig Arts, legal representative, Brasschaat, BE;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
The present invention relates to HIV replication inhibitors of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1 to 4; Rrepresents hydrogen; aryl; formyl; Calkylcarbonyl; Calkyloxycarbonyl; optionally substituted Calkyl; CalkyloxyCalkylcarbonyl substituted with Calkyloxycarbonyl; Ror Rrepresents hydrogen; hydroxy; halo; optionally substituted Calkyl; optionally substituted Calkenyl; optionally substituted Calkynyl; Ccycloalkyl; Calkyloxy; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhaloCalkyl; polyhaloCalkyloxy; polyhaloCalkylthio; —S(═O)R; —NH—S(═O)R; —C(═O)R; —NHC(═O)H; —C(═O)NHNH; NHC(═O)R; C(═NH)R; or R; Ror Rrepresents cyano; aminocarbonyl; amino; halo; NHR; NRR; —C(═O)—NHR; —C(═O)—NRR; —C(═O)—R; —CH═N—NH—C(═O)—R; optionally substituted Calkyl; optionally substituted Calkyloxy; optionally substituted CalkyloxyCalkyl; optionally substituted Calkenyl; optionally substituted Calkynyl; —C(═N—O—R)—Calkyl; Ror —X—R; Xor Xrepresents —NR—; —NH—NH—; —N═N—; —O—; —C(═O)—; —Calkanediyl-; —CHOH—; —S—; —S(═O)—; —X—Calkanediyl-; —Calkanediyl-X—; or —Calkanediyl-X—Calkanediyl-; their use as a medicine, their use for the manufacture of a medicament for the treatment or the prevention of HIV infection; their processes for preparation and pharmaceutical compositions comprising them.