The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 12, 2011

Filed:

Jan. 05, 2009
Applicants:

Karlheinz Baumann, Efringen-Kirchen, DE;

Alexander Flohr, Loerrach, DE;

Erwin Goetschi, Reinach BL, CH;

Helmut Jacobsen, Schopfheim, DE;

Synese Jolidon, Blauen, CH;

Thomas Luebbers, Loerrach, DE;

Inventors:

Karlheinz Baumann, Efringen-Kirchen, DE;

Alexander Flohr, Loerrach, DE;

Erwin Goetschi, Reinach BL, CH;

Helmut Jacobsen, Schopfheim, DE;

Synese Jolidon, Blauen, CH;

Thomas Luebbers, Loerrach, DE;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/4365 (2006.01); A61K 31/426 (2006.01); C07D 471/04 (2006.01); C07D 401/10 (2006.01); C07D 277/82 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to compounds of formula wherein R, R, R, R, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica or Down syndrome.


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