The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2011
Filed:
Jun. 03, 2004
Kazuhito Yamada, Ikoma, JP;
Yasumasa Sasaki, Ikoma, JP;
Fumitaka Tasaka, Ikoma, JP;
Mitsuaki Kuwano, Ikoma, JP;
Kazuhito Yamada, Ikoma, JP;
Yasumasa Sasaki, Ikoma, JP;
Fumitaka Tasaka, Ikoma, JP;
Mitsuaki Kuwano, Ikoma, JP;
Santen Pharmaceutical Co., Ltd., Osaka-shi, Osaka, JP;
Abstract
An object of the present invention is to provide a solvent which is able to produce microparticles where content of the drug is still high and no initial burst takes place even when a drug having a low solubility in a halogenated hydrocarbon solvent is used. The present invention provides a process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising a first solvent: halogenated hydrocarbon, and a second solvent: a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.