The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2011
Filed:
Jun. 24, 2005
Enrico Cappelletti, Seregno, IT;
Luciano Lattuada, Bussero, IT;
Karen E. Linder, Kingston, NJ (US);
Edmund Marinelli, Lawrenceville, NJ (US);
Palaniappa Nanjappan, Princeton, NJ (US);
Natarajan Raju, Kendall Park, NJ (US);
Kondareddiar Ramalingam, Dayton, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
Michael Tweedle, Princeton, NJ (US);
Enrico Cappelletti, Seregno, IT;
Luciano Lattuada, Bussero, IT;
Karen E. Linder, Kingston, NJ (US);
Edmund Marinelli, Lawrenceville, NJ (US);
Palaniappa Nanjappan, Princeton, NJ (US);
Natarajan Raju, Kendall Park, NJ (US);
Kondareddiar Ramalingam, Dayton, NJ (US);
Rolf E. Swenson, Princeton, NJ (US);
Michael Tweedle, Princeton, NJ (US);
Bracco Imaging S.p.A., Milan, IT;
Abstract
New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.