The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2011
Filed:
Jan. 04, 2009
Eckhard Wolf, Vierkirchen, DE;
Simone Renner, München, DE;
Barbara Kessler, München, DE;
Rüdiger Wanke, München, DE;
Nadja Herbach, München, DE;
Alexander Pfeifer, Bonn, DE;
Andreas Hofmann, Bonn, DE;
Eckhard Wolf, Vierkirchen, DE;
Simone Renner, München, DE;
Barbara Kessler, München, DE;
Rüdiger Wanke, München, DE;
Nadja Herbach, München, DE;
Alexander Pfeifer, Bonn, DE;
Andreas Hofmann, Bonn, DE;
Ludwig-Maximilians-Universitat, Munich, DE;
MWM Biomodels GmbH, Tiefenbach, DE;
Abstract
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.