The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2011
Filed:
Dec. 07, 2007
Kande Kankanamalage Dayarathna Amarasinghe, Latham, NY (US);
Michael James Rishel, Rensselaer, NY (US);
Sean Richard Dinn, Delmar, NY (US);
Bruce Fletcher Johnson, Scotia, NY (US);
Kande Kankanamalage Dayarathna Amarasinghe, Latham, NY (US);
Michael James Rishel, Rensselaer, NY (US);
Sean Richard Dinn, Delmar, NY (US);
Bruce Fletcher Johnson, Scotia, NY (US);
Other;
Abstract
The present invention provides novel fluorophilic compounds having structure VII wherein Ris a C-Caliphatic, a C-Ccycloaliphatic, or a C-Caromatic radical comprising at least one functional group susceptible to reaction with nucleophilic fluoride ion or an electrophilic fluorinating agent; Ris a C-Caliphatic radical; Ris hydrogen or a C-Caliphatic radical; Ris hydrogen or a C-Caliphatic radical; and Ris hydrogen, a C-Caliphatic radical, a C-Ccycloaliphatic radical, or a C-Caromatic radical. The fluorophilic compounds are provided in both racemic and enantiomerically enriched forms and are useful as intermediates in the preparation of novel PET imaging agents and probes useful in the discovery and performance assessment of PET imaging agents. The fluorophilic compounds are particularly useful in the preparation of PET imaging agents and probes having a high affinity for VMAT-2, a biomarker implicated in human diabetes and other illnesses such as Parkinson's disease.