The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2011
Filed:
Apr. 10, 2007
Maria Flores, Madrid, ES;
Andres Francesh, Madrid, ES;
Pilar Gallego, Madrid, ES;
Jose Luis Chicharro, Madrid, ES;
Maria Zarzuelo, Madrid, ES;
Carolina Fernandez, Madrid, ES;
Ignacio Manzanares, Madrid, ES;
Maria Flores, Madrid, ES;
Andres Francesh, Madrid, ES;
Pilar Gallego, Madrid, ES;
Jose Luis Chicharro, Madrid, ES;
Maria Zarzuelo, Madrid, ES;
Carolina Fernandez, Madrid, ES;
Ignacio Manzanares, Madrid, ES;
Pharma Mar, S.A., , ES;
Abstract
This invention relates to antitumoral ecteinascidin derivatives that contain a fused ecteinascidin five ring system with a 1,4-bridge having the structure of formula (VIa) or (VIb) as described herein and compounds in which the —NHor —OH of the 1,4-bridge is derivatized, and related pharmaceutical compositions and methods. Such ecteinascidin derivatives include, but are not limited to, those compounds having formula (XVIIb): in which Rand Rtogether form a group of formula (VIa) or (VIb) as described herein, and R, R, R, R, R, R, and Rare as defined herein.