The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2011
Filed:
Mar. 09, 2005
Francisco Javier Agejas-chicharro, Madrid, ES;
Bruce Anthony Dressman, Indianapolis, IN (US);
Jose Antonio Martinez Perez, Madrid, ES;
James Allen Monn, Indianapolis, IN (US);
Mohammad Sadegh Zia-ebrahimi, Indianapolis, IN (US);
Sonia Gutierrez Sanfeliciano, Madrid, ES;
Steven Marc Massey, Indianapolis, IN (US);
Steven Scott Henry, New Palestine, IN (US);
Francisco Javier Agejas-Chicharro, Madrid, ES;
Bruce Anthony Dressman, Indianapolis, IN (US);
Jose Antonio Martinez Perez, Madrid, ES;
James Allen Monn, Indianapolis, IN (US);
Mohammad Sadegh Zia-Ebrahimi, Indianapolis, IN (US);
Sonia Gutierrez Sanfeliciano, Madrid, ES;
Steven Marc Massey, Indianapolis, IN (US);
Steven Scott Henry, New Palestine, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C-Calkyl, C-Calkoxy, C-Cacyl, halo, amino, nitro, cyano, hydroxy, C-Cacylamino, C-Calkylsulfonylamino, mono-, di- or trifluorinated C-Calkyl, substituents which may be the same or different and may bear a CONH, CONHCH, CON(CH), COH, COCH, OCF, CHNHCOCH, CHNH, CHN(CH), CHCN, CHOH, CHNHSOCH, CHN(CH)(CH)CN, CHN(CH)CH(CH), CHNHCH(CH), CHNH(CH)CH, CHNHCOR, CHNHCHCH, CHNHCHNHCOC(CH), or N(S(O)CH)substituent; Ris hydrogen, halo, R, CN, C(NOH)R, C(NO—R)R, (CH)COR, (CH)OR, COR, CF, SR, S(O)R, S(O)R, COCHCOR, NHSOR, NHCOR, C(NOR)NH, CHOCOR, (CH)NH, CON(CH)(CH)NHCOR, COR, CONH, CSNH, C(NH)NHOR, (CH)N(CH), or CONHNHCOR; Ris 1,2-ethenediyl or 1,2-ethynediyl; Ris hydrogen or C-Calkyl; Ris C-Calkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.