The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 29, 2011

Filed:

Dec. 29, 2006
Applicants:

Amjad Ali, Freehold, NJ (US);

Zhijian LU, Clinton, NJ (US);

Peter J. Sinclair, Scotch Plains, NJ (US);

Yi-heng Chen, Whippany, NJ (US);

Cameron J. Smith, Lawrenceville, NJ (US);

Hong LI, Edison, NJ (US);

Inventors:

Amjad Ali, Freehold, NJ (US);

Zhijian Lu, Clinton, NJ (US);

Peter J. Sinclair, Scotch Plains, NJ (US);

Yi-Heng Chen, Whippany, NJ (US);

Cameron J. Smith, Lawrenceville, NJ (US);

Hong Li, Edison, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4166 (2006.01); A61K 31/44 (2006.01); A61K 31/506 (2006.01); C07D 239/34 (2006.01); C07D 413/10 (2006.01); C07D 263/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.


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