The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2011
Filed:
Oct. 08, 2009
Qi Chen, Wallingford, PA (US);
Qiong Cheng, Wilmington, DE (US);
Kevin Michael Croker, Hockessin, DE (US);
Thomas Eduard Friedmann, Hockessin, DE (US);
Kristin Ruebling-jass, Wilmington, DE (US);
Qi Chen, Wallingford, PA (US);
Qiong Cheng, Wilmington, DE (US);
Kevin Michael Croker, Hockessin, DE (US);
Thomas Eduard Friedmann, Hockessin, DE (US);
Kristin Ruebling-Jass, Wilmington, DE (US);
E.I. du Pont de Nemours and Company, Wilmington, DE (US);
Abstract
Disrupting the expression of endogenoushost cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production. The addition of a genetic modification to the coding region of gene yejM further enhances peptide production and facilitates easier downstream processing. Recombinanthost cells are provided as well as methods of using such host cells for heterologous peptide production.