The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Jul. 09, 2004
Ana Martinez Gil, Madrid, ES;
Isabel Dorronsoro Diaz, Madrid, ES;
Laura Rubio Arrieta, Madrid, ES;
Diana Alonso Gordillo, Madrid, ES;
Ana Fuertes Huerta, Madrid, ES;
Susana Morales-alcelay, Madrid, ES;
Maria Del Monte Millan, Madrid, ES;
Esther Garcia Palomero, Madrid, ES;
Paola Usan Egea, Madrid, ES;
Celia DE Austria, Madrid, ES;
Miguel Medina Padilla, Madrid, ES;
Pilar Munoz Ruiz, Madrid, ES;
Ana Martinez Gil, Madrid, ES;
Isabel Dorronsoro Diaz, Madrid, ES;
Laura Rubio Arrieta, Madrid, ES;
Diana Alonso Gordillo, Madrid, ES;
Ana Fuertes Huerta, Madrid, ES;
Susana Morales-Alcelay, Madrid, ES;
Maria Del Monte Millan, Madrid, ES;
Esther Garcia Palomero, Madrid, ES;
Paola Usan Egea, Madrid, ES;
Celia De Austria, Madrid, ES;
Miguel Medina Padilla, Madrid, ES;
Pilar Munoz Ruiz, Madrid, ES;
Noscira, S.A., , ES;
Abstract
The invention provides compounds of formula: which have a tacrine moiety connected to an heterocyclic moiety through a linker. Through careful selection of the substituents and the linker, the activity and selectivity towards acetylcholinesterase can be modulated. The compounds show potent AChE inhibition activities together with modifications in the β-amyloid aggregation properties by binding simultaneously to the catalytic and peripheral AChE sites. They are useful in the treatment of AChE mediated diseases, such as the Alzheimer's disease.