The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Jan. 21, 2009
Robert Edward Johnston, Chapel Hill, NC (US);
Salim Abdol Karim, Durban, ZA;
Lynn Morris, Randburg, ZA;
Ronald Swanstrom, Chapel Hill, NC (US);
Carolyn Williamson, Cape Town, ZA;
Robert Edward Johnston, Chapel Hill, NC (US);
Salim Abdol Karim, Durban, ZA;
Lynn Morris, Randburg, ZA;
Ronald Swanstrom, Chapel Hill, NC (US);
Carolyn Williamson, Cape Town, ZA;
Medical Research Council, Cape Town, ZA;
University of Cape Town Observatory, Cape Town, ZA;
University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Alphavax, Incorporated, Research Triangle Park, NC (US);
Abstract
Embodiments of the invention provide processes for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. A process for the selection of HIV subtype isolates comprises the steps of isolating viruses from recently infected subjects; generating a consensus sequence for at least part of at least one HIV gene by identifying the most common codon or amino acid among the isolated viruses; and selecting the isolated virus or viruses with a high sequence identity to the consensus sequence. HIV-1 subtype C isolates, designated Du422, Du 151 and Du 179 (assigned Accession Numbers 01032114, 00072724 and 00072725, respectively, by the European Collection of Cell Cultures) are also provided.