The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Feb. 11, 2003
Applicants:
Yingfu LI, Dundas, CA;
John Brennan, Dundas, CA;
Shirley Mei, Vancouver, CA;
Zhongjie Liu, Hamilton, CA;
Inventors:
Yingfu Li, Dundas, CA;
John Brennan, Dundas, CA;
Shirley Mei, Vancouver, CA;
Zhongjie Liu, Hamilton, CA;
Assignee:
McMaster University, Hamilton, Ontario, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods for the selection of novel signaling allosteric DNA enzymes are provided. In particular, fluorescent signaling allosteric DNA enzymes are described. The selection system is based on the cleavage of an ribonucleotide flanked by a fluorophore modified nucleotide and a quencher modified oligonucleotide. Both cis-acting and trans-acting allosteric DNA enzymes are identified, as well as aptamer/DNA enzyme conjugates.