The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Mar. 22, 2005
Jianyong Chen, Ann Arbor, MI (US);
Zaneta Nikolovska-coleska, Ann Arbor, MI (US);
Dajun Yang, Rockville, MD (US);
Shaomeng Wang, Saline, MI (US);
Haiying Sun, Ann Arbor, MI (US);
Liang Xu, Ann Arbor, MI (US);
Zengjian HU, Gaithersburg, MD (US);
Jianyong Chen, Ann Arbor, MI (US);
Zaneta Nikolovska-Coleska, Ann Arbor, MI (US);
Dajun Yang, Rockville, MD (US);
Shaomeng Wang, Saline, MI (US);
Haiying Sun, Ann Arbor, MI (US);
Liang Xu, Ann Arbor, MI (US);
Zengjian Hu, Gaithersburg, MD (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).