The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Jan. 13, 2006
Ognjen Culic, Zagreb, HR;
Martina Bosnar, Zagreb, HR;
Sulejman Alihodzic, Zagreb, HR;
Gorjana Lazarevski, Zagreb, HR;
Zorica Marusic Istuk, Zagreb, HR;
Antun Hutinec, Zagreb, HR;
Vanja Vela, Zagreb, HR;
Goran Kragol, Zagreb, HR;
Ognjen Culic, Zagreb, HR;
Martina Bosnar, Zagreb, HR;
Sulejman Alihodzic, Zagreb, HR;
Gorjana Lazarevski, Zagreb, HR;
Zorica Marusic Istuk, Zagreb, HR;
Antun Hutinec, Zagreb, HR;
Vanja Vela, Zagreb, HR;
Goran Kragol, Zagreb, HR;
GlaxoSmithKline istrazivacki centar Zagreb d.o.o., Zagreb, HR;
Abstract
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.