The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Jul. 16, 2004
Applicants:
Thomas J. Gardella, Needham, MA (US);
Naoto Shimizu, Shizuoka, JP;
Henry M. Kronenberg, Belmont, MA (US);
John T. Potts, Jr., Newton, MA (US);
Inventors:
Thomas J. Gardella, Needham, MA (US);
Naoto Shimizu, Shizuoka, JP;
Henry M. Kronenberg, Belmont, MA (US);
John T. Potts, Jr., Newton, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/29 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane ('J') domain of the receptor. The J domain is the region of the receptor that spans the seven transmembrane domain and the extracellular loops.