The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
May. 23, 2008
Lars Soegaard Nielsen, Nivaa, DK;
Dietmar Weilguny, Virum, DK;
Anne Bondgaard Tolstrup, Hillroed, DK;
Finn C. Wiberg, Farum, DK;
Christian Muller, Vaerlose, DK;
Lars Soegaard Nielsen, Nivaa, DK;
Dietmar Weilguny, Virum, DK;
Anne Bondgaard Tolstrup, Hillroed, DK;
Finn C. Wiberg, Farum, DK;
Christian Muller, Vaerlose, DK;
Symphogen A/S, Lyngby, DK;
Abstract
The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one member of the collection, which encodes a distinct member of a polyclonal protein. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The nucleic acid sequence is introduced into the cells by transfection with a collection of vectors. The present method is suitable for manufacturing recombinant polyclonal antibodies for therapeutic uses.