The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2011
Filed:
Jan. 19, 2007
Jeffrey S. Fedan, Morgantown, WV (US);
Yi Jing, Morgantown, WV (US);
Michael Van Scott, Greenville, NC (US);
Jeffrey S. Fedan, Morgantown, WV (US);
Yi Jing, Morgantown, WV (US);
Michael Van Scott, Greenville, NC (US);
The United States of America as represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
East Carolina University, Greenville, NC (US);
Centers for Disease Control and Prevention, Atlanta, GA (US);
Abstract
Apparatus and methods for measuring smooth muscles responses (relaxation and contraction), transepithelial potential difference, and/or transepithelial impedance of an intact trachea in vitro. In particular embodiments, the apparatus includes a perfusion device on which an extracted, intact trachea is mounted. The perfusion device and the trachea are immersed in an extraluminal bath, which is isolated from the perfusion liquid flowing through the trachea. A set of voltage-sensing electrodes is provided for measuring the transepithelial potential difference across the trachea wall. A set of current electrodes is provided for inducing an electrical current to flow across the trachea wall in order to determine transepithelial impedance.