The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2011
Filed:
Aug. 03, 2006
Andrea Cappelli, Civitella Marittima, IT;
Maurizio Anzini, Pianella, IT;
Mariangela Biava, Rome, IT;
Francesco Makovec, Lesmo, IT;
Antonio Giordani, Pavia, IT;
Gianfranco Caselli, Milan, IT;
Lucio Claudio Rovati, Monza, IT;
Andrea Cappelli, Civitella Marittima, IT;
Maurizio Anzini, Pianella, IT;
Mariangela Biava, Rome, IT;
Francesco Makovec, Lesmo, IT;
Antonio Giordani, Pavia, IT;
Gianfranco Caselli, Milan, IT;
Lucio Claudio Rovati, Monza, IT;
Rottapharm S.p.A., Milan, IT;
Abstract
This invention relates to 3-substituted-1,5-diaryl-2-alkyl-pyrroles of Formula I, pharmaceutical compositions containing them, and to their use for the pharmacological treatment of pain and COX-2 over-activation associated disorders. Compounds of this invention are new pyrrole derivatives bearing in position -3 of the pyrrole ring, several variously functionalized, not aliphatic, side chains which confer to the compounds a relevant COX-2 potency and selectivity along with a remarkable oral efficacy. Phenyl rings in position -1 and -5 are variously substituted, but compounds of particular interest are those substituted in position -5 with 4-methylsulphonyl-phenyl or with 4-aminosulphonyl-phenyl groups.