Pyrrole derivatives with angiotensin ii antagonist activity

Abstract

Compounds which may be represented by the general formula (I) shown below and in which: Ris a group independently selected from among: CHO, —COOH, —CHOH Ris hydrogen or a linear or branched C-Calkyl group Ris hydrogen or a halogen group selected from among Cl and Br Ris a linear or branched C-Calkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the ATreceptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.