The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2011
Filed:
Jun. 10, 2003
John DE Koning, The Hague, NL;
Anne Christensen, Bergen, NO;
Frank Schwede, Bassum, DE;
Hans Gottfired Genieser, Lemwerder, DE;
Stein Doskeland, Nesttun, NO;
Johannes Bos, Bunnik, NL;
John De Koning, The Hague, NL;
Anne Christensen, Bergen, NO;
Frank Schwede, Bassum, DE;
Hans Gottfired Genieser, Lemwerder, DE;
Stein Doskeland, Nesttun, NO;
Johannes Bos, Bunnik, NL;
Univisitair Medisch Centrum Utrecht, Utrecht, NL;
Abstract
The present invention relates to novel compounds for modulating the activity of exchange proteins directly activated by cAMP (Epacs). In particular, the present invention relates to cAMP analogues that specifically modulate the activity of Epacs. Examples of the compounds of the invention are substituted deoxyadenosine-cyclic monosphosphates. The invention further relates to pharmaceutical compositions comprising the novel compounds, and the use of the compounds in the treatment of diseases like cancer, chronic inflammation, thrombosis and/or type-2 diabetes mellitus in humans and/or animals.