The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Jan. 22, 2009
Feng Xu, Staten Island, NY (US);
Mary M. Kim, Cheltenham, PA (US);
Yoshinori Kohmura, Ibaraki, JP;
Tricia Sladicka, Schenectady, NY (US);
Jonathan D. Rosen, Iowa City, IA (US);
Michael J. Zacuto, Jersey City, NJ (US);
Feng Xu, Staten Island, NY (US);
Mary M. Kim, Cheltenham, PA (US);
Yoshinori Kohmura, Ibaraki, JP;
Tricia Sladicka, Schenectady, NY (US);
Jonathan D. Rosen, Iowa City, IA (US);
Michael J. Zacuto, Jersey City, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Banyu Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I): wherein Ar is optionally substituted phenyl and P is a primary amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.