The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Nov. 29, 2007
Michael James Rishel, Rensselaer, NY (US);
Kande Kankanamalage Dayarathna Amarasinghe, Latham, NY (US);
Sean Richard Dinn, Delmar, NY (US);
Bruce Fletcher Johnson, Scotia, NY (US);
Michael James Rishel, Rensselaer, NY (US);
Kande Kankanamalage Dayarathna Amarasinghe, Latham, NY (US);
Sean Richard Dinn, Delmar, NY (US);
Bruce Fletcher Johnson, Scotia, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
The present invention provides novel alpha-fluoroalkyl compounds having structure I and the corresponding dihydrotetrabenazine compounds IV wherein Ris a C-Cfluorinated aliphatic radical; Ris hydrogen or a C-Caliphatic radical; and Ris hydrogen or a C-Caliphatic radical. The alpha-fluoroalkyl compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The alpha-fluoroalkyl compounds are shown to possess high affinity for VMAT-2, a biomarker implicated in human diabetes. The alpha-fluoroalkyl compounds comprising a fluorine-18 group are useful as PET imaging agents targeting the VMAT-2 biomarker. The non-radiolabled alpha-fluoroalkyl compounds are useful as probes for the discovery of PET imaging agents.