The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Nov. 30, 2006
Omayra Padilla DE Jesus, Guilderland, NY (US);
Faisal Ahmed Syud, Clifton Park, NY (US);
Rong Zhang, Niskayuna, NY (US);
Ernest William Kovacs, Albany, NY (US);
Omayra Padilla De Jesus, Guilderland, NY (US);
Faisal Ahmed Syud, Clifton Park, NY (US);
Rong Zhang, Niskayuna, NY (US);
Ernest William Kovacs, Albany, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.