The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Jul. 20, 2009
Michele L. R. Heffernan, Worcester, MA (US);
Qun Kevin Fang, Wellesley, MA (US);
Robert J. Foglesong, Durham, NC (US);
Seth C. Hopkins, Clinton, MA (US);
Cyprian O. Ogbu, Durham, NC (US);
Mustapha Soukri, Raleigh, NC (US);
Kerry L. Spear, Concord, MA (US);
Michele L. R. Heffernan, Worcester, MA (US);
Qun Kevin Fang, Wellesley, MA (US);
Robert J. Foglesong, Durham, NC (US);
Seth C. Hopkins, Clinton, MA (US);
Cyprian O. Ogbu, Durham, NC (US);
Mustapha Soukri, Raleigh, NC (US);
Kerry L. Spear, Concord, MA (US);
Sepracor, Inc., Marlborough, MA (US);
Abstract
The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.