The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Jan. 21, 2005
Jérôme Emile Georges Guillemont, Ande, FR;
Elisabeth Therese Jeanne Pasquier, Le Neubourg, FR;
David Francis Alain Lancois, Louviers, FR;
Jérôme Emile Georges Guillemont, Ande, FR;
Elisabeth Therese Jeanne Pasquier, Le Neubourg, FR;
David Francis Alain Lancois, Louviers, FR;
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of mycobacterial diseases. In particular, compounds are claimed in which, independently from each other, Ris halo; p=1; Ris optionally substituted alkyloxy, alkyl, Ar, Het, or a radical of formula Ris optionally substituted Ar or Het; q=1, Rand Reach independently are alkyl; Ris hydrogen or a radical of formula r is equal to 0 or 1 and Ris hydrogen or Ar. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of mycobacterial diseases and a process for preparing the claimed compounds.