The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Jul. 24, 2007
Sang-kyou Lee, Seoul, KR;
Seung-kyou Lee, Kyeunnggi-Do, KR;
Yang-soo Jang, Seoul, KR;
Ki-chul Hwang, Seoul, KR;
Sang-Kyou Lee, Seoul, KR;
Seung-Kyou Lee, Kyeunnggi-Do, KR;
Yang-Soo Jang, Seoul, KR;
Ki-Chul Hwang, Seoul, KR;
ForHumanTech. Co., Ltd., Suwon, KR;
Abstract
The present invention relates to pharmaceutical compositions for treating diseases and conditions caused by ischemia. The pharmaceutical compositions contain a conjugate of a phospholipase (PL) polypeptide and a protein transduction domain (PTD). PLC-δ plays a major role in the regulation of cytosolic calcium levels. During myocardial ischemia, cytosolic calcium accumulation mediates pathogenic changes. According to the present invention, ischemic diseases or conditions leading to hypoxia in tissues, such as the heart and the brain, can be prevented or alleviated by administration of a PTD-PL conjugate.