The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2011
Filed:
Feb. 02, 2007
Mark Carle Connelly, Doylestown, PA (US);
Gerald V. Doyle, Radnor, PA (US);
Galla Chandra Rao, Princeton Junction, NJ (US);
Leon W. M. M. Terstappen, Huntingdon Valley, PA (US);
Mark Carle Connelly, Doylestown, PA (US);
Gerald V. Doyle, Radnor, PA (US);
Galla Chandra Rao, Princeton Junction, NJ (US);
Leon W. M. M. Terstappen, Huntingdon Valley, PA (US);
Veridex, LLC, Raritan, NJ (US);
Abstract
Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ transplants, surgical trauma and cancer. This invention provides a method for assessing the levels of CEC which vary between different studies using a sensitive enrichment, imaging, and enumberation analysis. CD146 is one of the most specific endothelium-associated cell-surface antigens which can be used in image cytometry. CEC analysis provides an essential tool in prognostic/diagnostic evaluation in the clinic.