The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2011
Filed:
Apr. 29, 2007
Zheng Yu, Beijing, CN;
Min Zhou, Beijing, CN;
Enyun Shen, Beijing, CN;
Xianzhao Jia, Beijing, CN;
Yang Song, Beijing, CN;
Zheng Yu, Beijing, CN;
Min Zhou, Beijing, CN;
Enyun Shen, Beijing, CN;
Xianzhao Jia, Beijing, CN;
Yang Song, Beijing, CN;
Beijing Cotimes Biotech Ltd., Beijing, CN;
Abstract
This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.