The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2011
Filed:
Mar. 05, 2007
Dario Alessi, Dundee, GB;
Mirjana Andjelkovic, Basel, CH;
Philip Cohen, Invergowrie, GB;
Peter David Cron, Basel, CH;
Darren Cross, Macclesfield, GB;
Brian A. Hemmings, Bettingen, CH;
Dario Alessi, Dundee, GB;
Mirjana Andjelkovic, Basel, CH;
Philip Cohen, Invergowrie, GB;
Peter David Cron, Basel, CH;
Darren Cross, Macclesfield, GB;
Brian A. Hemmings, Bettingen, CH;
Novartis AG, , CH;
Abstract
The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor.