The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Aug. 16, 2007
Peter Christopher Ray, Newhouse, GB;
Steven Laats, Newhouse, GB;
John Richard Morphy, Newhouse, GB;
Brad Sherborne, Newhouse, GB;
Peter Christopher Ray, Newhouse, GB;
Steven Laats, Newhouse, GB;
John Richard Morphy, Newhouse, GB;
Brad Sherborne, Newhouse, GB;
N.V. Organon, Oss, NL;
Abstract
The present invention relates to 6-substituted isoquinoline derivatives having the general Formula I wherein X is O, S or NH; Y is OH or NH; m is 0, 1 or 2; n is 0 or 1; o is 0 or 1; Ris H, when Y is NH; or Ris H, (C)alkyl or halogen, when Y is OH; Rand Rare independently H, (C)alkyl or halogen; Ris H or (C)alkyl, optionally substituted with halogen, (C)cycloalkyl, (C)aryl or a saturated 5- or 6-membered heterocyclic ring comprising 1-3 heteroatoms independently selected from O, S and N, the (C)aryl and heterocyclic ring being optionally substituted with (C)alkyl, (C)alkyloxy or halogen; Ris H or (C)alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that the compounds of Formula I wherein X is O, Y is OH , n is 0 and m+o=2 are excluded, to pharmaceutical compositions comprising the same, as well as to the use of said 6-substituted isoquinoline derivatives for the preparation of a medicament for the treatment of ROCK-I related disorders such as glaucoma, hypertension and atherosclerosis.