The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Jun. 12, 2008
Timothy Colin Hancox, Slough, GB;
Neil Anthony Pegg, Slough, GB;
Mandy Christine Beswick, Harlow, GB;
Toby Jonathan Blench, Harlow, GB;
Elsa Amandine Dechaux, Harlow, GB;
Janusz Jozef Kulagowski, Harlow, GB;
Alan John Nadin, Harlow, GB;
Stephen Price, Harlow, GB;
Timothy Colin Hancox, Slough, GB;
Neil Anthony Pegg, Slough, GB;
Mandy Christine Beswick, Harlow, GB;
Toby Jonathan Blench, Harlow, GB;
Elsa Amandine Dechaux, Harlow, GB;
Janusz Jozef Kulagowski, Harlow, GB;
Alan John Nadin, Harlow, GB;
Stephen Price, Harlow, GB;
F. Hoffmann-La Roche AG, , GB;
Abstract
Thiazolopyrimidines of formula (I): wherein W represents a thiazole ring; Rand Rform, together with the N atom to which they are attached, a group of the following formula (IIa): in which A is a ring system; m is 0, 1 or 2; Ris H or C-Calkyl; and Ris an indole group which is unsubstituted or substituted; and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PD kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.